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FRONTLINE Plus Spot On Flea & Tick for Dogs


  • NEW double action FRONTLINE PLUS protects your pet & home
  • KILLS FLEAS on your pet within 24 hours
  • KILLS TICKS on your pet within 48 hours
Save up to 37% Save 35%
Original price £28.99
Original price £28.99 - Original price £66.99
Original price £28.99
Current price £18.71
£18.71 - £42.30
Current price £18.71

Buy one Frontline Plus Flea & Tick Treatment for Cats 6-Pack and get one 6-Pack half price! Offer available on 6-Packs only, and discount will be applied at checkout.

PLEASE NOTE: We can only dispense one year's worth of this product per one registered pet.

KILLS FLEAS, TICKS & LICE, PLUS STOPS FLEA EGGS HATCHING IN YOUR HOME FRONTLINE Plus® is an advanced formula within the FRONTLINE® range of flea and tick treatments. It not only kills fleas but also stops their eggs from hatching and infesting your home. Unlike other flea treatments, FRONTLINE Plus® kills ticks too, helping to reduce the risk of tick-borne disease transmission. Use every 4 weeks all year round for optimum flea and tick protection.


  • Kills fleas on your pet within 24 hours
  • Stops flea eggs hatching in your home
  • Kills ticks within 48 hours, helping reduce the risk of tick-borne diseases
  • Kills lice

    FRONTLINE Plus® is a veterinary medicine with a robust safety profile. It can be applied to dogs from 8 weeks of age that weigh at least 2 kg. It can also be used in pregnant and lactating bitches.

    Bathing/shampooing/water exposure does not affect the efficacy of the product as long as it doesn't occur more than once a week.

    If your dog is unwell, please see your vet for advice before you apply a flea treatment.

    FRONTLINE Plus® for dogs is not suitable for use on rabbits.

    Available in 3 and 6 dose packs. FRONTLINE Plus® contains fipronil and (S)-methoprene. UK: NFA-VPS. Further information is available in the SPC or from Boehringer Ingelheim Animal Health UK Ltd, RG12 8YS, UK. FRONTLINE® is a registered trademark of the Boehringer Ingelheim Group. ©2020 Boehringer Ingelheim Animal Health UK Ltd. All rights reserved. Use medicines responsibly.

Brand - Frontline

Frontline Plus Spot On Dog S, M, L, XL
Therapeutic indication:Pharmaceuticals: Ectoparasiticides: For dogs
Active ingredient:Fipronil, (S)-methoprene
Product:Frontline Plus Spot On Dog
Product index:Frontline Plus Spot On Dog
Qualitative and quantitative composition
Frontline Plus Spot-On Dog
Weight (kg)
Volume of unit dose (ml)
Fipronil (mg)
(S)-methoprene (mg)
Butylhydroxytoluene (E321) (mg)
Butylhydroxyanisole (E320) (mg)
Pharmaceutical form
Spot-on solution. Clear amber solution.
Clinical particulars
Target species
Indications for use
-To be used against infestations with fleas, alone or in association with ticks and/or biting lice.
-Treatment of flea infestations (Ctenocephalides spp.). Insecticidal efficacy against new infestations with adult fleas persist for 8 weeks. Prevention of the multiplication of fleas by inhibiting the development of eggs (ovicidal activity) and larvae and pupae (larvicidal activity) originating from eggs laid by adult fleas for eight weeks after application.
-Treatment of tick infestations (Ixodes ricinus, Dermacentor variabilis, Dermacentor reticulatus, Rhipicephalus sanguineus). The product has a persistent acaricidal efficacy for up to 4 weeks against ticks.
-Treatment of infestations with biting lice (Trichodectes canis).
In the absence of available data, the product should not be used on puppies less than 8 weeks old.
Do not use on sick (e.g. systemic diseases, fever) or convalescent animals.
Do not use in rabbits, as adverse reactions with even mortality could occur. In absence of studies, the use of the product is not recommended in non-target species. This product is specifically developed for dogs. Do not use in cats and ferrets, as this could lead to overdosing.
Special warnings for each target species
Bathing/immersion in water within 2 days after application of the product and more frequent bathing than once a week should be avoided, as no study has been performed to investigate how this affects the efficacy of the product. Emollient shampoos can be used prior to treatment, but reduce the duration of protection against fleas to approximately 5 weeks when used weekly after application of the product. Weekly bathing with a 2% chlorhexidine medicated shampoo did not affect efficacy against fleas during a 6 week long study.
Dogs should not be allowed to swim in watercourses for 2 days after application (See “Special precautions for disposal” section)
There may be an attachment of a few ticks. For this reason a transmission of infectious diseases cannot be completely excluded if conditions are unfavourable.
Fleas from pets often infest the animal's basket, bedding and regular resting areas such as carpets and soft furnishings which should be treated, in case of massive infestation and at the beginning of the control measures, with a suitable insecticide and vacuumed regularly.
When treating infestations of parasites, all in-contact animals should be treated with an appropriate product at the same time.
Special precautions for use in animals
Avoid contact with the animal's eyes.
It is important to make sure that the product is applied to an area where the animal cannot lick it off and to make sure that animals do not lick each other following treatment.
Animals should be weighed accurately prior to treatment.
Special precautions to be taken by the person administering the product to animals
Keep pipettes in original packaging until ready to use.
This product can cause mucous membrane, skin and eye irritation. Therefore, contact of the product with mouth, skin and eyes should be avoided.
If the product is accidentally swallowed, seek medical advice immediately and show the package leaflet to the physician.
Animals or operators with a known hypersensitivity (allergy) to insecticides or alcohol should avoid contact with this product. Avoid contents coming into contact with the fingers. If this occurs, wash hands with soap and water.
After accidental ocular exposure the eye should be rinsed carefully with pure water. Wash hands after use.
Treated animals should not be handled until the application site is dry, and children should not be allowed to play with treated animals until the application site is dry. It is therefore recommended that animals are not treated during the day, but should be treated during the early evening, and that recently treated animals are not allowed to sleep with owners, especially children.
Do not smoke, drink or eat during application.
Adverse reactions
Among the very rare suspected adverse reactions, transient skin reactions on the application site (skin discoloration, local hair loss, itching, redness) and general itching or hair loss have been reported after use. Excessive salivation, reversible nervous signs (increased sensitivity to stimulation, depression, other nervous signs), vomiting or respiratory symptoms have also been observed after use.
If licking occurs, a brief period of excessive salivation may be observed due mainly to the nature of the carrier.
Do not overdose.
Use during pregnancy, lactation or lay
The product can be used during pregnancy and lactation.
Do not use simultaneously with other flea products which are applied directly on to the animal.
Amounts to be administered and administration route
By topical application to the skin. In the absence of safety studies, the minimum treatment interval is 4 weeks.
Weight (kg)
2 - 10
1 x 0.67 ml pipette
>10 - 20
1 x 1.34 ml pipette
>20 - 40
1 x 2.68 ml pipette
1 x 4.02 ml pipette
Method of administration:
Hold the pipette upright. Tap the narrow part of the pipette to ensure the contents remain within the main body of the pipette. Snap back the tip. Part the coat on the back of the animal at the base of the neck in front of the shoulder blades until the skin is visible. Place the tip of the pipette on the skin and squeeze the pipette several times to empty its contents completely and directly onto the skin in one spot.
Temporary changes to the coat (clumped/greasy hair) may be noted at the application site.
No adverse effects were observed in target animal safety studies in 8 week-old puppies, growing dogs and dogs weighing about 2 kg treated once at five times the recommended dose. The risk of experiencing adverse effects (see Adverse Reactions section) may however increase when overdosing, so animals should always be treated with the correct pipette size according to bodyweight.
Pharmacological particulars
Pharmacotherapeutic group: Ectoparasiticides for topical use incl. insecticides QP53. The product is an insecticidal and acaricidal solution for topical use, containing an association of an adulticidal active ingredient, fipronil, in combination with an ovicidal and larvicidal active ingredient, (S)-methoprene.
Pharmacodynamic properties
Fipronil is an insecticide and acaricide belonging to the phenylpyrazole family. It acts by interacting with ligand-gated chloride channels, in particular those gated by the neurotransmitter gamma-aminobutyric acid (GABA), thereby blocking pre- and post-synaptic transfer of chloride ions across cell membranes. This results in uncontrolled activity of the central nervous system and death of insects or acarines. Fipronil kills fleas within 24 hours and ticks (Dermacentor reticulatus, Dermacentor variabilis, Rhipicephalus sanguineus, Ixodes scapularis, Ixodes ricinus, Haemaphysalis longicornis, Haemaphysalis flava, Haemaphysalis campanulata) and lice within 48 hours post-exposure.
(S)-Methoprene is an insect growth regulator (IGR) of the class of compounds known as juvenile hormone analogues that inhibit the development of immature stages of insects. This compound mimics the action of juvenile hormone and causes impaired development and death of the developing stages of fleas. The on-animal ovicidal activity of (S)-methoprene results from either direct penetration of the eggshell of newly laid eggs or from absorption through the cuticle of the adult fleas. (S)-methoprene is also effective in preventing flea larvae and pupae from developing, which prevents contamination of the environment of treated animals with the immature stages of fleas.
Pharmaceutical particulars
Butylhydroxyanisole (E320), Butylhydroxytoluene (E321), Ethanol Polysorbate 80 (E433), Povidone, Diethylene glycol monoethyl ether
Major incompatibilities
None known.
Shelf life
Shelf life of the veterinary medicinal product as packaged for sale: 3 years
Special precautions for storage
Do not store above 30°C. Store in the original package.
Immediate packaging
Box of 1 or 2 blister card (s) of 3 pipettes, or blister card of 1 pipette, with a scored tip, each containing either 0.67 ml, 1.34 ml, 2.68 ml or 4.02 ml.
Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal product should be disposed of in accordance with local requirements. Fipronil and (S)-methoprene may adversely affect aquatic organisms. Do not contaminate ponds, waterways or ditches with the product or empty containers.
Marketing Authorisation Number
Vm 08327/4268-71
Legal category
Legal category:NFA-VPS
GTIN description:Frontline Plus Spot-On Dog Small x 3 pipettes
GTIN description:Frontline Plus Spot-On Dog Small x 6 pipettes
GTIN description:Frontline Plus Spot-On Dog Small x 1 pipette
GTIN description:Frontline Plus Spot-On Dog Medium x 3 pipettes
GTIN description:Frontline Plus Spot-On Dog Medium x 6 pipettes
GTIN description:Frontline Plus Spot-On Dog Medium x 1 pipette
GTIN description:Frontline Plus Spot-On Dog Large x 3 pipettes
GTIN description:Frontline Plus Spot-On Dog Large x 6 pipettes
GTIN description:Frontline Plus Spot-On Dog Large x 1 pipette
GTIN description:Frontline Plus Spot-On Dog X-Large x 3 pipettes
GTIN description:Frontline Plus Spot-On Dog X-Large x 6 pipettes
GTIN description:Frontline Plus Spot-On Dog X-Large x 1 pipette

Shipping Fees

Orders under £29 - £4.99

Orders £29 or more – Free


Delivery Methods

Petwell ship via Royal Mail and DPD, your carrier is dictated by the weight and size of your order. Once you receive your order confirmation email, you will then be sent a tracking number allowing you to follow your parcel on its journey to your door.  


Unfortunately, we cannot currently deliver outside of the British Isles

How long will it take to deliver my order?

Most orders are despatched within 1-2 working days. Once despatched, the estimated shipping times are up to 3 working days. Please track your parcel for accurate delivery times.


 (Please note couriers do not usually deliver on Saturday or Sunday)